10 Questions with Assistant Professor Matthew Brook

Q1. Who inspired you to become a scientist? Natural curiosity instilled as a boy on walks with my Grandad and, probably Prof. Dave Rickwood who supervised my undergraduate project. Inexplicably, he let an inexperienced student, with a very poor record of lab practical attendance, use one of the first confocal microscopes in the UK. I […]

Translatomics for Arabidopsis thaliana, Mouse Heart and Aquaporin in grapevine

Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Rincon Diaz, D. et al. find that gcn2 Arabidopsis mutants maintain wild-type-like protein synthesis rates under methyl jasmonate exposure. Warren C.M et al. find […]

Translatomics for cellular stress, hypoxic stress and stalled nascent chains

Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Douglas, T. et al. identify HOIL-1 as an important regulator of ribosome homeostasis during cellular stress. Elhamamsy, A. et al. uncover previously unrecognized role […]

Translatomics for rRNA, mouse and kidney

Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Yang et al. showed that METTL5-driven rRNA methylation promotes prostate cancer by enhancing IRF7/DNA2 signaling to maintain mitochondrial function and prevent stress-induced mitophagy. Zang […]

Translatomics for pertussis, ncORFs, and tRNA hydroxylation

Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Leguia et al. employed RNA-seq and ribosome profiling and demonstrated substantial DTP and DTaP vaccine-induced changes in gene expression. Deutsch et al. integrate RNA-seq […]