Biological Impact of Codon Optimality in Translation

1. Introduction When delving into the realms of codon optimality, we must first take a step back to observe our definitions and origins. At the most fundamental level, our genome is constructed from four basic building blocks, the nucleotides adenine (A), cytosine (C), guanine (G) and thymine (T). When a transcript (utilising a uridine (U) […]

Translatomics Insights on SARS-CoV-2 Mechanisms

Viruses, lacking their own cellular organelles, necessarily hijack its host’s translational machinery, namely the ribosome, to produce the proteins required for replication and propagation. Additionally, many viruses utilise the recoding phenomenon of frameshifting to significantly increase the genomic information within their small genomes. As such, translatomics is a key area of study in the field […]