10 Questions with Professor Leandro Castellano
Q1. Who inspired you to become a scientist?
I wasn’t inspired by a particular person. Instead, I was fascinated by molecular biology during university. The idea that tiny molecular changes can have such a huge impact on health and disease really captured my imagination. I wanted to contribute to our understanding of how diseases develop and, ultimately, how we can treat them more effectively.
Q2. What drives your research interest?
I’m driven by a desire to understand the molecular networks that make some cancers so difficult to treat. If we can decode these complex biological processes, we can identify new therapeutic opportunities and improve outcomes for patients. The possibility of making even a small difference to cancer treatment is what motivates me every day.
Q3. What is your current research focus?
My research focuses on RNA molecules, particularly non-coding RNAs such as microRNAs. Although they do not produce proteins, they play a critical role in regulating gene activity and can drive cancer development and progression. Understanding how these molecules work may reveal new biomarkers and therapeutic targets.
Q4. Who are your current scientific influences?
I’m inspired by scientists whose discoveries have fundamentally changed our understanding of biology and medicine. The researchers who uncovered the role of microRNAs are a great example. Their work transformed an entire field and was ultimately recognised with a Nobel Prize, showing how curiosity-driven research can have a lasting impact.
Q5. If you hadn’t become a scientist, what would your dream job be?
It’s hard to imagine doing anything else, but if I hadn’t pursued science, I think I would have enjoyed building a biotechnology company. The idea of translating scientific discoveries into real-world solutions that can benefit patients is something I find incredibly exciting.
Q6. What are your hobbies?
I love reading, although being a scientist already involves a lot of it! To switch off, I enjoy reading about topics completely unrelated to research. I often get so absorbed in a good book that I find myself reading late into the evening. I also enjoy spending as much time as possible with my family and watching movies.
Q7. What books influenced you the most?
A book that had a lasting impact on me is The Gene by Siddhartha Mukherjee. It beautifully combines science, history and human stories, showing how biological discovery can shape society. I’m also drawn to books that explore big ideas and challenge the way we think about the world.
Q8. What are your favourite movies?
I enjoy films with strong storytelling and memorable characters. Some of my favourites include Pulp Fiction, Trainspotting, Joker, Parasite, and One Battle After Another. I’m drawn to films that challenge conventions, explore complex characters, and leave you thinking long after the credits roll.
Q9. What advice would you give your 18-year old self?
Be a better student and make the most of every opportunity to learn. Knowledge compounds over time, and the habits you build early can have a huge impact on your future. I’d also remind myself not to worry too much about having all the answers straight away.
Q10. What, in your opinion, is the “next big thing” in the field of scientific research?
I think the next big leap will come from combining artificial intelligence with advanced molecular biology. The ability to analyse vast biological datasets and identify subtle patterns more efficiently could accelerate discoveries and help researchers develop more precise diagnostic tools and treatments. This has the potential to transform personalised medicine and improve patient outcomes.
About Professor Leandro Castellano
Leandro Castellano is an Associate Professor in RNA Biology at the University of Sussex, where he serves as Head of the Department of Biochemistry and Biomedicine and Co-Director of the Sussex RNA Research Centre. He is passionate about understanding how non-coding RNAs drive cancer development and treatment resistance, with the aim of improving patient outcomes.