Consequat mauris nunc congue nisi vitae suscipit tellus. Quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Mauris ultrices eros in cursus turpis massa tincidunt. Integer quis auctor elit sed vulputate mi sit amet. Quis varius quam quisque id diam vel quam. Ultrices sagittis orci a scelerisque purus semper eget duis. Accumsan tortor posuere ac […]
Consequat mauris nunc congue nisi vitae suscipit tellus. Quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Mauris ultrices eros in cursus turpis massa tincidunt. Integer quis auctor elit sed vulputate mi sit amet. Quis varius quam quisque id diam vel quam. Ultrices sagittis orci a scelerisque purus semper eget duis. Accumsan tortor posuere ac […]
1. Introduction When delving into the realms of codon optimality, we must first take a step back to observe our definitions and origins. At the most fundamental level, our genome is constructed from four basic building blocks, the nucleotides adenine (A), cytosine (C), guanine (G) and thymine (T). When a transcript (utilising a uridine (U) […]
Viruses, lacking their own cellular organelles, necessarily hijack its host’s translational machinery, namely the ribosome, to produce the proteins required for replication and propagation. Additionally, many viruses utilise the recoding phenomenon of frameshifting to significantly increase the genomic information within their small genomes. As such, translatomics is a key area of study in the field […]
Nonsense mutations, single nucleotide changes which replaces a codon that encodes for an amino acid with a stop codon resulting in truncated protein products, give rise to approximately 11% of inherited diseases in humans. Nonsense suppression therapeutics may act as viable treatments for such diseases by allowing ribosomes to read through premature termination codons and […]
