Introduction Mutations that introduce a premature termination codon (PTC) into the mRNA lead to the synthesis of truncated and usually non-functional proteins that may cause disease. Furthermore, mRNA surveillance pathways, such as the nonsense-mediated mRNA decay (NMD) pathway, can compound the impact of PTCs by degrading mutant mRNAs to prevent the accumulation of potentially hazardous […]
Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Awad S et al. find that longer genes in S. cerevisiae have lower ribosome drop-off rates, while Rocha AL et al. characterise the function of the uORF-encoded microprotein of SLC35A4 […]
Introduction Gene annotation is a cornerstone of genomics, providing insights into the functional elements of the genome and enabling researchers to understand the roles of genes in health, disease, and development. However, due to the complexity of many genomes, gene annotation is a daunting task, and traditional methods often fall short in capturing the full […]
Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Barlit et al. present a comprehensive genome-wide analysis of protein synthesis in yeast under iron scarcity using ribosome profiling (Ribo-Seq). Wei et al. use single-cell RNA-Seq of Drosophila to investigate […]
Melanoma is a particularly aggressive cancer, well known for its ability to rapidly metastasize to other organs, making early diagnosis crucial. Alarmingly, it is also currently one of the fast growing cancers in the Western world (1), and so further research in this area is particularly important. Control of protein synthesis in cancer is crucial, […]
