Translation is a tightly controlled mechanism in response to abiotic stress tolerance in plants, partly due to how energetically expensive translation is. Under hostile conditions, plants significantly downregulate growth, choosing to conserve resources until more favourable conditions return. Translation also plays a key role in rapidly producing protective proteins, increasing the likelihood of survival. With […]
https://eirnabio.com//srv/htdocs/wp-content/uploads/2023/06/Question-40-1.mp4 In the realm of drug discovery, understanding the mechanism of action of therapeutic compounds is crucial, and ribosome profiling (Ribo-seq) has emerged as a powerful tool for this purpose. Despite its strengths, the application of Ribo-seq in a high-throughput manner poses practical limitations. The resource-intensive nature of the technology makes it challenging to triage […]
Introduction Mutations that introduce a premature termination codon (PTC) into the mRNA lead to the synthesis of truncated and usually non-functional proteins that may cause disease. Furthermore, mRNA surveillance pathways, such as the nonsense-mediated mRNA decay (NMD) pathway, can compound the impact of PTCs by degrading mutant mRNAs to prevent the accumulation of potentially hazardous […]
Introduction Gene annotation is a cornerstone of genomics, providing insights into the functional elements of the genome and enabling researchers to understand the roles of genes in health, disease, and development. However, due to the complexity of many genomes, gene annotation is a daunting task, and traditional methods often fall short in capturing the full […]
1. Introduction When delving into the realms of codon optimality, we must first take a step back to observe our definitions and origins. At the most fundamental level, our genome is constructed from four basic building blocks, the nucleotides adenine (A), cytosine (C), guanine (G) and thymine (T). When a transcript (utilising a uridine (U) […]
