Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Kim et al. induced stress on the eIF4F complex to investigate its function in modulating gene expression to promote cellular survival. Musaev et al. showed that Upf1 destablised mRNAs with […]
Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Ero et al. showed that the formation of large ribosomal subunit (50S) of E. coli was essential for its ribosome biogenesis, contributing to antibiotic development. Hacisuleyman et al. presented that uORF:eIF4G2 binding […]
Introduction Mutations that introduce a premature termination codon (PTC) into the mRNA lead to the synthesis of truncated and usually non-functional proteins that may cause disease. Furthermore, mRNA surveillance pathways, such as the nonsense-mediated mRNA decay (NMD) pathway, can compound the impact of PTCs by degrading mutant mRNAs to prevent the accumulation of potentially hazardous […]
Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Awad S et al. find that longer genes in S. cerevisiae have lower ribosome drop-off rates, while Rocha AL et al. characterise the function of the uORF-encoded microprotein of SLC35A4 […]
Introduction Gene annotation is a cornerstone of genomics, providing insights into the functional elements of the genome and enabling researchers to understand the roles of genes in health, disease, and development. However, due to the complexity of many genomes, gene annotation is a daunting task, and traditional methods often fall short in capturing the full […]
