Knowledge Hub – Page 10

Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers,Â...

Melanoma is a particularly aggressive cancer, well known for its ability to rapidly metastasize to other organs, making early diagnosis crucial. Alarmingly, it is also currently one of the fast growin...

1. Introduction When delving into the realms of codon optimality, we must first take a step back to observe our definitions and origins. At the most fundamental level, our genome is constructed from f...

Viruses, lacking their own cellular organelles, necessarily hijack its host’s translational machinery, namely the ribosome, to produce the proteins required for replication and propagation. Addition...

Nonsense mutations, single nucleotide changes which replaces a codon that encodes for an amino acid with a stop codon resulting in truncated protein products, give rise to approximately 11% of inherit...

In the present day, the vast majority of pharmaceutical therapeutics target specific proteins or enzymatic reactions. However, due to conformational challenges, in addition to other issues, a wide num...

Upstream open reading frames (uORFs) are sequences with start and stop codons found upstream of the main protein coding region in an area known as the 5’ untranslated region (UTR). uORFs can vary by...

Cell Specificity in Translation Transcription and translation are often thought to be coupled processes, with a rise in mRNA transcripts typically associated with an increase in translation. And while...

Translation is a key process in a wide range of cancers, being significantly altered to drive its initiation and progression. Practically all oncogenic signalling pathways (including RAS–MAPK, PI3Kâ...

Identifying what proteins are being expressed at a cellular level in response to a drug or as a consequence (or cause) of a pathological state is fundamental to our understanding of disease phenotypes...

1. Introduction Ribosome Profiling (Ribo-seq) is a deep-sequencing technique developed by Nicholas Ingolia and Jonathan Weissman that facilitates a genome-wide view of translation in vivo (1).  This...

Translation within the context of viral-host interaction is a crucially important factor in determining the propagation of the invading pathogen. Due to their lack of cellular organelles, it is a requ...