A revolutionary bioinformatics platform
What if you could view your translatomic data using an interactive platform providing you with comprehensive and reproducible analysis without the need for any prior bioinformatic experience? Well, now you can. EIRNABio has developed an interactive, secure, browser-based data analytics platform called EIRNABio Connect
Advanced Analysis & Visualization
Faster turn-around times for data results and exploration
Once we have pre-processed and mapped your sequence data, it will be immediately available to explore and interrogate. Videos and easy-to-follow help pages are provided on the platform itself enabling users to fully capitalize on the platform’s built-in analytical and visualization capabilities. Workshops can also be hosted for first-time users.
Key Benefits
- Prior bioinformatic experience is not required. The platform will empower all stakeholders to independently explore and analyze their data.
- Plots are interactive, allowing users to zoom, pan as well as show/hide different elements of the plot.
- Access to the same data and parameter settings means reproducible analysis by different stakeholders.
- Easy-to-share dynamically generated plots via the ‘short code’ system.
- Ability to cross-reference data from different projects as multiple project data – even for different organisms and different treatments – will all be hosted on the same platform.
- Secure login access for each user.
- Downloadable plots in multiple formats, and/or corresponding data for further analysis
- Continuous platform development to incorporate innovative approaches for Ribo-seq and RNA-seq data interrogation.
A full suite of Ribo-seq and RNA-seq data analysis functionality available to clients from the outset
A full suite of Ribo-seq and RNA-seq data analysis tools will be available including QC, DE analysis, Alternate translated ORF prediction, Pause prediction and more. For each transcript, a direct link from each of the above outputs will be available so you can dynamically generate ribosome profiles with zoom functionality for direct on-the-fly exploration of gene transcripts.
Additionally, single comparative ribosome profiles can be generated for comparing potential changes in RPF and RNA-seq read distribution across sample conditions. This can be particularly useful following DE analysis for genes that are predicted to be regulated at the translational or transcriptional level upon treatment compared to control or wild-type conditions.
New Feature: Integrated Genome Browser
EIRNABio-Connect has expanded its visualization capabilities with the addition of a fully interactive Genome Browser. While our transcriptome-based browser excels at visualizing data at the mRNA level – ideal for discerning specific translational events without the noise of long intronic regions – the Genome Browser offers a broader perspective.
By aligning data to the chromosome level, users can now explore complete gene structures, including exons, introns, and promoters. This is particularly advantageous for identifying unannotated events, such as novel transcript isoforms or translons in intergenic regions.
The true power of EIRNABio-Connect lies in the seamless interfacing between these two approaches. Users can easily switch between genomic and transcriptomic views, ensuring comprehensive exploration of Ribo-seq and RNA-seq data -from raw chromosomal alignments to precise sub-codon profiles.
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