Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Cao et al. employ polysome profiling to uncover the mechanism by which circMYLK4 alters energy metabolism in skeletal muscle. Cheng et al. utilize ribosome profiling to demonstrate how a small nucleolar RNA […]
Recent Publications Harnessing the Power of Translatomics Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Schaefer et al. document a novel function of SOX2 in translational regulating extracellular matrix and developmental gene transcripts. Boraas et al. uncover a role of G3BP1 […]
Translation is a tightly controlled mechanism in response to abiotic stress tolerance in plants, partly due to how energetically expensive translation is. Under hostile conditions, plants significantly downregulate growth, choosing to conserve resources until more favourable conditions return. Translation also plays a key role in rapidly producing protective proteins, increasing the likelihood of survival. With […]
What is RNA-seq based differential gene expression’s (DGE) blind spot? RNA-seq is a powerful and widely employed tool to quantify gene expression at the RNA level. However, that there are several limitations when using RNA-seq only derived gene expression counts to predict differential gene expression (DGE) across different treatments or conditions. The primary blind spot […]
Ribosome Profiling: A Window into Translation Dynamics Ribosome profiling provides a snapshot of active translation by sequencing ribosome-protected mRNA fragments1 allowing the identification of which mRNAs are being translated, thereby offering insights into the translational control of gene expression. Ribo-seq data are instrumental in revealing the intricacies of translation initiation, elongation, and termination, as well […]
