Complete gene expression profiling

Numerous diseases, ranging from cancer to neurodegenerative disorders, exhibit dysregulated translation as a central feature of their pathogenesis. Translation, the process by which mRNA is translated into functional proteins, is finely regulated to maintain cellular homeostasis. However, aberrant translation can lead to the production of harmful proteins, disruption of cellular processes, and ultimately disease onset and progression. Traditional approaches such as RNA-seq and proteomics offer valuable insights into gene expression patterns and protein profiles. However, they often fail to capture the nuanced alterations occurring at the translational level, leaving critical gaps in the understanding of disease mechanisms. 

Ribosome Profiling (i.e. an integrated analysis of RNA-seq and Ribo-seq) helps bridge these gaps, allowing for exploration of translational dysregulation which is often the hallmark of many complex diseases. By capturing ribosome-protected mRNA fragments, Ribo-seq provides a dynamic snapshot of active translation events which can be used to pinpoint aberrant translation events. Ribo-seq identifies novel disease-associated genes, pathways, and regulatory networks, offering unprecedented opportunities for therapeutic intervention. In-depth expertise is indispensable for the thorough analysis of Ribo-seq data, as it requires nuanced understanding of biological context to accurately decipher ribosome occupancy patterns and extract meaningful insights into disease processes.

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