Do you have the passion to lead cutting-edge R&D that underpins the development of groundbreaking drugs and diagnostics? Does the opportunity to shape and commercialize transformative research platforms excite you? If so, you may be a great fit for EIRNABio as we empower biotech and pharmaceutical companies with deeper insights into RNA translation and protein […]
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Cell 2024 Transposable element exonization generates a reservoir of evolving and functional protein isoforms Arribas, Y., Baudon, B., Rotival, M., Suárez, G., Bonté, P., Casas, V., Roubert, A., Klein, P., Bonnin, E., Mchich, B., Legoix, P., Baulande, S., Sadaccal, B., Diharce, J., Waterfall, J.J., Etchebest, C., Carrascal, M., Goudot, C., Quintana-Murci, L., Burbage, M., Merlotti,
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Cell Reports 2024 Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells Amiri, M., Kiniry, S.J., Possemato, A.P., Mahmood, N., Basiri, T., Dufour, C.R., Tabatabaei, N., Deng, Q., Bellucci, M.A., Harwalkar, K., Stokes, M.P., Giguère, V., Kaufman, R.J., Yamanaka, Y., Baranov, P.V., Tahmasebi, S. and Sonenberg, N. PNAS 2023 Nontriplet feature
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In the realm of drug discovery, understanding the mechanism of action of therapeutic compounds is crucial, and ribosome profiling (Ribo-seq) has emerged as a powerful tool for this purpose. Despite its strengths, the application of Ribo-seq in a high-throughput manner poses practical limitations. The resource-intensive nature of the technology makes it challenging to triage large
By Gary Loughran, Head of Biology Introduction Mutations that introduce a premature termination codon (PTC) into the mRNA lead to the synthesis of truncated and usually non-functional proteins that may cause disease. Furthermore, mRNA surveillance pathways, such as the nonsense-mediated mRNA decay (NMD) pathway, can compound the impact of PTCs by degrading mutant mRNAs to
By Gary Loughran, Head of Biology Gene annotation is a cornerstone of genomics, providing insights into the functional elements of the genome and enabling researchers to understand the roles of genes in health, disease, and development. However, due to the complexity of many genomes, gene annotation is a daunting task, and traditional methods often fall
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