Nonsense Suppression Therapy Nonsense mutations, single nucleotide changes which replaces a codon that encodes for an amino acid with a stop codon resulting in truncated
Translatomics in Action Blogs
Small Molecules Targeting Translation In the present day, the vast majority of pharmaceutical therapeutics target specific proteins or enzymatic reactions. However, due to conformational challenges,
Translation Elongation Rates In order to maintain a healthy proteome, the ribosome must not only generate sequences of peptides in sufficient quantities to serve their
Optimising Biotherapeutic Protein Yields The primary determinants for successful recombinant protein expression are high expression levels of the recombinant genes, translation efficacy and post-translational modifications.
Complete Differential Gene Expression Identifying what proteins are being expressed at a cellular level in response to a drug or as a consequence (or cause)