Nonsense Suppression Therapy Nonsense mutations, single nucleotide changes which replaces a codon that encodes for an amino acid with a stop codon resulting in truncated
Small Molecules Targeting Translation In the present day, the vast majority of pharmaceutical therapeutics target specific proteins or enzymatic reactions. However, due to conformational challenges,
uORF detection Upstream open reading frames (uORFs) are sequences with start and stop codons found upstream of the main protein coding region in an area
Translation Elongation Rates In order to maintain a healthy proteome, the ribosome must not only generate sequences of peptides in sufficient quantities to serve their
Ribosome Pausing The process of translation is characterized by variation in the local decoding rates of specific mRNA codons. There are known cases where pausing or
Optimising Biotherapeutic Protein Yields The primary determinants for successful recombinant protein expression are high expression levels of the recombinant genes, translation efficacy and post-translational modifications.
Abiotic Stress Tolerance Translation is a tightly controlled mechanism in response to abiotic stress tolerance in plants, partly due to how energetically expensive this process
Biofuels and Commodities With the advent of genetic engineering, a revolution occurred within the sector of biofuel and commodity production. Suddenly, microbes were being utilised
Complete Differential Gene Expression Identifying what proteins are being expressed at a cellular level in response to a drug or as a consequence (or cause)
Viral-Host Interaction Translation within the context of viral-host interaction is a crucially important factor in determining the propagation of the invading pathogen. Due to their
